Creative Bios

  Antibod ies , a major component of adaptive immunity, play a critical role in protective and pathogenic immune responses. In r ecent years, a wide range of antibodies is discovered as candidates of cancer therapeutic agents, including the reconstructive molecules, bispecific antibodies (BsAbs).   About Bispecific Antibody   Bispecific antibodies, as its name indicates, consists of two antigen-binding sites, which can simultaneously bind two separate and unique antigens (or different epitopes of the same antigen). This structure is  typically designed to bind to two targets, one on a cancer cell and one on an immune cell, act ivating or redirecting immune effector cells with the goal of getting the immune cell to kill the cancer cell by antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement-dependent cytotoxicity (CDC) and other cytotoxic mechanisms.   U nique biological and pharmacological properties, ...

  The incidence and   c ase fatality rate of cancer is increasing with the deterioration of the global environment and the changes in people's living habits, which urges the development of anti-tumor drugs and related studies. Bispecific antibodies  (BsAbs) are one of the novel concepts that are regarded as the second-generation antibodies for tumor therapies with broad prospects.   Bispecific antibodies are featured  with a structure of binding to two different epitopes on the same or different antigens, which make them more efficient in the process of killing tumor cells. BsAbs can facilitate the recruitment and activation of immune cells and the blocking of tumor signaling pathways, as well as bind to Fc receptors and drugs.   T  cells present in the blood circulation of the whole body are one of the most important  and powerful immune cells to attack tumor cells. However, it's difficult for T cells to focus on a specific cancerous part of the ...

Model organisms (Model-org) are non-human species, from which researchers can get insights into other organisms in biological research processes. Various model organism species such as zebrafish, flies, yeast, and rice, greatly contribute to the basic and clinical research in animal husbandry, fishery ， agriculture, forestry, etc.   Investigations on model organisms can be aided by antibody labeling when samples of interest need to be detected, isolated, or purified, though the selection of a proper label can be a challenge.   To select the best antibody labeling way for our Model-org project, we then found Creative Biolabs, one of the most well-established CROs for antibody development. After a comprehensive discussion and consultancy with the scientists at Creative Biolabs, fluorescent tags were  suggested based on our research direction. Fluorescent labels are directly conjugated to the antibody of interest, indicating that we can directly detect the number of fluoresc...

  Human monoclonal antibody therapies, which embrace over 570 agents in the clinical field, have become one of the fastest-growing cancer treatment s . Now, a novel therapy based on bispecific antibodies may be a further refinement in oncology treatment that overcomes the limitations of current monoclonal antibody therapies.   What are Bispecific Antibodies?   Bispecific a ntibodies (BsAbs)  are engineered proteins that can simultaneously recognize and bind two separate and unique targets (antigens or different epitopes of the same antigen). Given the fact of dual functionalities, BsAbs are different from normal monoclonal antibodies.   Therapeutics and drugs based on bispecific antibodies are expected to be the next big advance in oncology, hematology in particular. Different from cytotoxic chemotherapy or targeted agents, the distinct mechanism of action of bispecific antibody drugs may enable patients to fight against cancers with  the immune system. ...

  Everything You Want to Know About Antibody Development   When foreign molecules, which are known as antigens, enter our body, antibodies will be released by B cells of the immune system to specifically bind to the antigens and finally clear out those “invaders”. Such a highly specific molecular recognition mechanism has inspired a variety of antibody development research and diagnostic applications nowadays, including IVD antibody development .   What is Antibody Development?   Antibody development is the process of creating and characterizing an antibody.   The timeline of developing antibodies starts from the injection of an antigen of interest into a host animal, so that the host’s immune system can detect it and generat e  the desired antibodies. Then, antibody development proceeds with finding and isolating the desired antibodies from the rest of the protein in sera.   The reset procedure of antibody development is varied as the desired antibodi...