Skip to main content

Why Customers Love Creative Biolabs’ Recombinant Antibodies?

 

Creative Biolabs is a leader in discovering and manufacturing recombinant antibodies. Its products and services propel research in the field of life sciences, solve challenges encountered in experiments, promote the development of medical diagnostics, and improve laboratory productivity.

 

Recombinant Antibodies developed by Creative Biolabs are inspired by its advanced research tools, professional team, and consistent dedication.

 

About recombinant antibodies (rAbs)

 

Taking advantage of the structure of conventional antibodies, rAbs are generated by synthetic genes and occur in vitro. Traditional monoclonal antibodies (mAbs) use B-cells to form hybridomas and produce the desired antibody clone. Different from the former, recombinant antibodies production code antibody genes into high-yield expression vectors. These vectors need to be introduced into bacteria, yeast, or other expression hosts to generate rAbs instead of using hybridomas and animals in the production process.

 

Recombinant antibody production outperforms traditional mAbs in many ways. It overcomes previous technical limitations, showing noticeable batches consistency, reproducibility, scalability, specificity with confirmed long-term supply.

 

rAbs can normally replace the traditional mAbs in most cases, such as biomedical science and toxicological research, without causing pain and discomfort to the animals.

 

Advantages of Creative Biolabs’ Recombinant Antibodies

 

Creative Biolabs delivers a variety of recombinant antibodies for researchers with commendable features.

 

Competitive ability to reproduce and control

Extraordinary specificity and sensitivity

Isotype conversion

Cost-effective process

Decreased production time

 

The recombinant antibody products of Creative Biolabs return powerful and positive signals and can be reproduced for several months in the host body. Covering thousands of genes and a wide range of applications, Creative Biolabs has developed different rAbs hosted by humans, goat, chicken, Armenian hamster, rat, sheep, rabbit, mouse, cattle, chimeric, Guinea pig, alpaca, etc.

 

These products allow researchers to isolate antibodies against antigens or antigen characteristics easily and take control of experimental conditions. Creative Biolabs develops recombinant antibodies to significantly shorten the experimental time and eliminate the ethical and animal welfare concerns for researchers.

 

As it was known, an antibody is structured with two heavy chains (VH) and two light chains (VL). Recombinant antibodies production clone the variable genes on heavy and light chains through PCR and design the required primers. Then experts at Creative Biolabs get highly efficient transformation with competent sources. Their advanced display technology will guarantee the reconstructed antibody expressions within large-scale production.

 

Besides, Creative Biolabs believes that a model of custom-service-centered business will optimize the drug research and development process. Therefore, based on the principle of producing recombinant antibodies, the team is glad to customize services and products for scientists with special project needs.

 

The Application of Recombinant Antibodies

 

Recombinant antibodies now have been long established in the use of research and treatments for cancer, autoimmune disorders, and other diseases because these antibody fragments can:

 

Shorten circulating half-life in serum

Distribute to broader tissue and penetrate tumors

Reduce cost and increase manufacturing scale

Form bispecific antibody fragments and other desired molecules.

 

Smaller size, easier engineering and manufacture process, and high tissue penetration, all these advantages grant recombinant antibodies a greater chance of success.

 

Creative Biolabs devotes all passions to engineering and manufacturing antibodies with extensive experience. Decades of efforts have merged into trustworthy antibody services and products. If you are interested in more recombinant antibody products or need help with your projects, please don’t hesitate to contact us.

 

 

Comments

Popular posts from this blog

How Haptens Differ from Antigens and Become Immunogens?

The  difference between antigens vs. haptens  is one the most concerning issues for people who are not familiar with them. As a matter of fact, antigens and haptens are similar in many ways. They are both molecules triggering immune responses and acting as antigenic agents. And they both work as immunogens and bind to antibodies although haptens in a different manner.   What distinguishes an antigen mostly from a hapten is that antigens are complete molecules spontaneously triggering immune response whereas haptens are fragmentary small molecules that are unable to elicit immune responses unless they are conjugated to a larger molecule, known as a carrier.   What are Antigens? Antigen s, including proteins, peptides, and polysaccharides, are immunogen   molecules  that can trigger immune response s or naturally bind to   immune   components . An antigen may have one or more epitopes, which are the determinants of recognition and binding to antibod...

Review: Creative Biolabs' Model-org Antibodies Fluorescently Labeling Services

Model organisms (Model-org) are non-human species, from which researchers can get insights into other organisms in biological research processes. Various model organism species such as zebrafish, flies, yeast, and rice, greatly contribute to the basic and clinical research in animal husbandry, fishery , agriculture, forestry, etc.   Investigations on model organisms can be aided by antibody labeling when samples of interest need to be detected, isolated, or purified, though the selection of a proper label can be a challenge.   To select the best antibody labeling way for our Model-org project, we then found Creative Biolabs, one of the most well-established CROs for antibody development. After a comprehensive discussion and consultancy with the scientists at Creative Biolabs, fluorescent tags were  suggested based on our research direction. Fluorescent labels are directly conjugated to the antibody of interest, indicating that we can directly detect the number of fluoresc...

Metagenomics Enhances Infectious Disease Surveillance

  Infectious lower respiratory diseases and diarrheal diseases are the leading causes of death globally . And the ongoing COVID-19 pandemic, which has contributed to 4.1 million deaths in 2019, once again is reminding the necessity of proactively identifying early signs of infectious disease outbreaks before things are getting worse. Conventional microbial diagnostics techniques would identify pathogens under specific culture conditions by serological detection of pathogen-associated antibodies or microbial genetic investigation using PCR, but these methods have been seen obvious shortcomings in pathogen coverage. It's highly required to find advanced scientific tools that are more sensitive even with a low microbial load or when targeted microorganisms are not suitable for  in vitro  culture, for which metagenomic approaches that can profile all DNA or RNA of a patient sample are increasingly catching the eyes of researchers.   How metagenomics can be used in infect...