Creative Biolabs is a leader in discovering and manufacturing recombinant antibodies. Its products and services propel research in the field of life sciences, solve challenges encountered in experiments, promote the development of medical diagnostics, and improve laboratory productivity.
Recombinant Antibodies developed by Creative Biolabs are inspired by its advanced research tools, professional team, and consistent dedication.
About recombinant antibodies (rAbs)
Taking advantage of the structure of conventional antibodies, rAbs are generated by synthetic genes and occur in vitro. Traditional monoclonal antibodies (mAbs) use B-cells to form hybridomas and produce the desired antibody clone. Different from the former, recombinant antibodies production code antibody genes into high-yield expression vectors. These vectors need to be introduced into bacteria, yeast, or other expression hosts to generate rAbs instead of using hybridomas and animals in the production process.
Recombinant antibody production outperforms traditional mAbs in many ways. It overcomes previous technical limitations, showing noticeable batches consistency, reproducibility, scalability, specificity with confirmed long-term supply.
rAbs can normally replace the traditional mAbs in most cases, such as biomedical science and toxicological research, without causing pain and discomfort to the animals.
Advantages of Creative Biolabs’ Recombinant Antibodies
Creative Biolabs delivers a variety of recombinant antibodies for researchers with commendable features.
l Competitive ability to reproduce and control
l Extraordinary specificity and sensitivity
l Isotype conversion
l Cost-effective process
l Decreased production time
The recombinant antibody products of Creative Biolabs return powerful and positive signals and can be reproduced for several months in the host body. Covering thousands of genes and a wide range of applications, Creative Biolabs has developed different rAbs hosted by humans, goat, chicken, Armenian hamster, rat, sheep, rabbit, mouse, cattle, chimeric, Guinea pig, alpaca, etc.
These products allow researchers to isolate antibodies against antigens or antigen characteristics easily and take control of experimental conditions. Creative Biolabs develops recombinant antibodies to significantly shorten the experimental time and eliminate the ethical and animal welfare concerns for researchers.
As it was known, an antibody is structured with two heavy chains (VH) and two light chains (VL). Recombinant antibodies production clone the variable genes on heavy and light chains through PCR and design the required primers. Then experts at Creative Biolabs get highly efficient transformation with competent sources. Their advanced display technology will guarantee the reconstructed antibody expressions within large-scale production.
Besides, Creative Biolabs believes that a model of custom-service-centered business will optimize the drug research and development process. Therefore, based on the principle of producing recombinant antibodies, the team is glad to customize services and products for scientists with special project needs.
The Application of Recombinant Antibodies
Recombinant antibodies now have been long established in the use of research and treatments for cancer, autoimmune disorders, and other diseases because these antibody fragments can:
l Shorten circulating half-life in serum
l Distribute to broader tissue and penetrate tumors
l Reduce cost and increase manufacturing scale
l Form bispecific antibody fragments and other desired molecules.
Smaller size, easier engineering and manufacture process, and high tissue penetration, all these advantages grant recombinant antibodies a greater chance of success.
Creative Biolabs devotes all passions to engineering and manufacturing antibodies with extensive experience. Decades of efforts have merged into trustworthy antibody services and products. If you are interested in more recombinant antibody products or need help with your projects, please don’t hesitate to contact us.
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