Skip to main content

Progress Made Toward NASH Diagnosis and Drug Discovery

 A buildup of fat in the liver could cause an aggressive type of nonalcoholic fatty liver disease (NAFLD), called nonalcoholic steatohepatitis (NASH) which is a condition with liver inflammation and damage. Most of the time, it causes no symptoms and no problems, while in some worse cases, the fat causes inflammation and damages liver cells, affecting the normal function of the liver or even leading to cirrhosis. Though the second leading indication for liver transplantation in the United States, NASH has no FDA-approved treatments currently. This is drawing concerns from all stakeholders, including patients and providers, for which experts call for a great deal of focus on understanding and addressing this important liver disease that impacts clinical outcomes and the quality of life.

 

Diagnosis of NASH

 

Because NASH are asymptomatic until patients are identified at advanced stages, a liver biopsy remains the gold standard for making early predictive and definitive NASH diagnosis and staging. However, the liver biopsy is an invasive procedure that has several drawbacks, including sampling error, high expense, side effects like pain and bleeding, and the impracticability of performing liver biopsies on all NASH patients. All these unfavorable factors are prompting the technology for developing reliable, precise, and noninvasive NASH diagnostic approaches.

 

Biomarkers, as noninvasive and reliable alternatives to liver biopsy, contribute to the early diagnosis of NASH by indicating biological characteristics in a normal or pathologic process. Conventional NASH biomarkers like liver enzymes have different drawbacks. And currently, it's not possible to identify fibrosis and steatosis, to early diagnose NASH, or to predict the disease progression with one biomarker alone single test. There are many novel noninvasive tests are in development, and multi-omics biomarkers, including those focusing on microbiota, seem to be promising if only combinatorial methods were standardized and implemented.

 

Treatment of NASH

 

Though no pharmacologic therapy has been approved to treat NASH and clinical advice on treating this disease is more about lifestyle modification based on body weight and exercise, the NASH therapeutic pipeline is robust.

 

As a matter of fact, there are approximately dozens of projects for NASH drug development with different mechanisms. They are being investigated in various phases of drug development, some of which undoubtedly would come across setbacks but numerous drugs still are showing great promise for the potential to treat NASH. With different endpoints like a histological improvement, NASH resolution, prevention of progression to cirrhosis, and fibrosis stage regression, some NASH drugs are expected to be approved on the basis of relatively short-term studies. However, it's also pointed out that in the race of developing medical treatment of NASH, lifestyle modification is still the most effective treatment currently available for NASH patients.

 

Researchers have a positive attitude toward the future of NASH drug approval and look forward to receiving approval for at least one additional serum biomarker in recent years. Also, as NASH is a complex and multiorgan disease involving different mechanisms of action, experts indicated that it would be beneficial to have several approved drugs to tailor different treatments for different patients.

 

Labels:

Comments

Post a Comment

Popular posts from this blog

Review: Creative Biolabs' Model-org Antibodies Fluorescently Labeling Services

Model organisms (Model-org) are non-human species, from which researchers can get insights into other organisms in biological research processes. Various model organism species such as zebrafish, flies, yeast, and rice, greatly contribute to the basic and clinical research in animal husbandry, fishery ， agriculture, forestry, etc.   Investigations on model organisms can be aided by antibody labeling when samples of interest need to be detected, isolated, or purified, though the selection of a proper label can be a challenge.   To select the best antibody labeling way for our Model-org project, we then found Creative Biolabs, one of the most well-established CROs for antibody development. After a comprehensive discussion and consultancy with the scientists at Creative Biolabs, fluorescent tags were  suggested based on our research direction. Fluorescent labels are directly conjugated to the antibody of interest, indicating that we can directly detect the number of fluoresc...
Post a Comment
Read more

Primary Antibody vs. Secondary Antibody, How to Choose?

  Antibodies (or immunoglobulins) are Y -shaped glycoproteins released by the immune system  to detect and bind to "foreign" substances , known as " antigens ", triggering a cascade of actions to destroy these foreign invaders. Scientists would develop different antibodies for research use, which basically can be classified into primary and secondary antibodies . However, how to choose the right type of antibodies for different immunoassays in experiment procedures, such as western blotting (WB), enzyme-linked immunosorbent assays (ELISA), and immunoprecipitation (IP), is one of the most common questions for green hands in the laboratory.   P rimary A ntibod y vs. Secondary Antibody   Antibodies could be categorized into two types based on the binding capability and experimental applications— primary   antibodies   and  secondary antibodies.   The main difference between these two types of antibodies is that primary antibody binds specifically to ...
Post a Comment
Read more

Lab-on-a-chip Technology: Detect Cancer Before a Tumor Formed

  Cancer is a condition characterized by uncontrollable cell growth or reproduction in a specific part of the body, which will ultimately invade surrounding tissues and metastasize to distant sites. Most of the time, cancer has been advanced and possibly spread throughout the body by the time it's diagnosed. Therefore, cancer diagnosis and treatment is a competition against time, for which efforts have been made to find informative biomarkers, such as mutated nucleic acids, secreted proteins, and tumor cells, that can indicate cancer at the relatively early stage.   Researchers at the Concordia University recently published a study in the journal Biosensors and Bioelectronics , which introduced a new liquid biopsy approach using lab-on-a-chip  technology, aiming at detecting cancer prior to the forming of a tumor.   M icrofluidic Chip to  Capture Cancer Biomarkers   Th is liquid biopsy method is developed on the basis of a microfluidic chip targeting extrac...
Post a Comment
Read more